Faculty Publication: Professor of Chemistry Bill Malachowski

Catalytic Enantioselective Birch–Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters

Authors: Andrew T. Krasley, William P. Malachowski, Hannah M. Terz, and Sabrina Tran Tien

Source: Organic Letters, Vol 20, March 21, 2018

Abstract: A new enantioselective desymmetrizing Mizoroki–Heck reaction is reported. The process affords high yields and enantioselectivities of tricyclic structures containing all-carbon quaternary stereocenters. The substrates for the reaction are efficiently synthesized from Birch reduction–alkylation of benzoic acid and benzoate esters.

Department of Chemistry